What is LMA in law?

What is LMA in law?

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Cancer is caused when cells somewhere in the body begin to grow out of control. There are many types of cancer. Cells in almost any part of the body can turn into cancer. For more information about cancer, how it starts and spreads, see What is cancer?

Leukemias are cancers that originate in cells that would normally mature into different types of blood cells. Most often, leukemia originates in early forms of white blood cells, but some leukemias begin in other types of blood cells. There are several types of leukemia that are divided based primarily on whether the leukemia is acute (fast growing) or chronic (slower growing), and whether it starts in myeloid cells or lymphoid cells.

Acute myeloid leukemia (AML) starts in the bone marrow (the soft part of the inside of certain bones, where new blood cells are made), but more often it also spreads quickly to the blood. Sometimes it spreads to other parts of the body, including the lymph nodes, liver, spleen, central nervous system (the brain and spinal cord) and testicles.

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Go to health professional versionImportant pointsAdult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow produces large numbers of abnormal blood cells.

Important pointsOnce acute myeloid leukemia is diagnosed, tests are done to find out if the cancer has spread to other parts of the body.Usually, the grade or spread of the cancer is described in terms of stages. In acute myeloid leukemia (AML), instead of staging, the subtype of AML and whether the disease has spread outside the blood and spinal cord are used to plan treatment.The following tests and procedures may be used to determine whether the leukemia has spread:There is no standard staging system for acute myeloid leukemia. The disease is described as untreated, in remission, refractory, or relapsed.Newly diagnosed acute myeloid leukemia (previously untreated)In previously untreated AML, the disease has just been diagnosed and has not been treated except to relieve signs and symptoms such as fever, bleeding, or pain. In addition, the following situations occur:Acute myeloid leukemia in remissionIn AML in remission, the disease has already been treated and the following situations occur:Refractory or relapsed acute myeloid leukemiaAfter treatment with chemotherapy, some patients with newly diagnosed AML will not obtain remission. This is called refractory cancer. In contrast, recurrent AML is cancer that has recurred (come back) after remission. The AML may come back in the blood or bone marrow.

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However, acute myeloid leukemia (AML) usually does not form tumors, but spreads throughout the bone marrow, and in some cases, has spread to other organs, such as the liver and spleen. Therefore, AML is not staged like most other cancers. Rather, the prognosis of a person with AML will depend on other information, such as the subtype of AML (determined by laboratory tests), the patient’s age, and other laboratory test results.

Two of the main systems that have been used to classify AML into subtypes are the French-American-British (FAB) classification and the more recent World Health Organization classification.

Subtypes M0 through M5 all begin in immature forms of white blood cells. M6 AML begins in very immature forms of red blood cells, while M7 AML begins in immature forms of platelet-producing cells.

Acute undifferentiated and biphenotypic leukemias are not strictly AML, but leukemias that have lymphocytic and myeloid features. They are sometimes called mixed biphenotypic acute leukemias (MPAL).


El tema ha suscitado tanto interés que prácticamente todos los despachos internacionales han publicado recientemente artículos para sus clientes al respecto. Puedes consultar estos artículos en los siguientes enlaces:

Definición de Efecto Adverso Material: “Efecto Adverso Material” con respecto a una parte significa un cambio o efecto material adverso en el negocio, las operaciones, la condición financiera, las propiedades o los pasivos de la parte tomada en su conjunto; siempre y cuando, sin embargo, no se considere que un Efecto Adverso Material incluya (i) cambios como resultado del anuncio de esta transacción, (ii) eventos o condiciones que surjan de cambios en las condiciones generales de negocios o económicas o (iii) cambios en los principios de contabilidad generalmente aceptados.

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Definición de Efecto Adverso Significativo: “Efecto Adverso Significativo” significa, respecto de cualquier parte en particular, cualquier cambio adverso de carácter sustancial en o que afectara al negocio, las operaciones, la situación financiera, los activos o pasivos, en cada caso conjuntamente considerados, de la parte afectada en cuestión sin que, no obstante, puedan entenderse incluidos en la definición de Efecto Adverso Significativo (i) aquellos cambios que fueran atribuibles al mero anuncio de la presente operación, (ii) cualesquiera hechos o situaciones que derivaran de cualquier cambio en la situación económica o empresarial de carácter general, ni (iii) cualesquiera modificaciones de los principios de contabilidad generalmente aceptados.